Assay Detail
Functional
CHEMBL915779
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of human HL60 cell differentiation to monocytes by NBT reduction assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
22-Alkyl-20-epi-1alpha,25-dihydroxyvitamin D3 compounds of superagonistic activity: syntheses, biological activities and interaction with the receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 9.66 | 10.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220846 | — | — | 1 | 10.74 |
| CHEMBL222195 | — | — | 1 | 10.24 |
| CHEMBL375811 | — | — | 1 | 8.98 |
| CHEMBL846 | CALCITRIOL | 4.0 | 1 | 8.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220846 | — | EC50 | = | 0.018 | nM | 10.74 |
| CHEMBL222195 | — | EC50 | = | 0.057 | nM | 10.24 |
| CHEMBL375811 | — | EC50 | = | 1.05 | nM | 8.98 |
| CHEMBL846 | CALCITRIOL | EC50 | = | 2.15 | nM | 8.67 |