Assay Detail
Binding
CHEMBL915808
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Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum FcB1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Aminopeptidase N (CHEMBL4117) ↗| Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum FcB1/Columbia |
Publication
Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 6.55 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL219777 | — | — | 1 | 8.22 |
| CHEMBL375521 | — | — | 1 | 7.89 |
| CHEMBL219611 | — | — | 1 | 7.39 |
| CHEMBL425291 | — | — | 1 | 7.35 |
| CHEMBL220996 | — | — | 1 | 7.34 |
| CHEMBL219618 | — | — | 1 | 7.24 |
| CHEMBL374479 | — | — | 1 | 7.04 |
| CHEMBL219612 | — | — | 1 | 6.97 |
| CHEMBL376198 | — | — | 1 | 6.96 |
| CHEMBL113827 | — | — | 1 | 6.90 |
| CHEMBL331784 | — | — | 1 | 6.90 |
| CHEMBL220389 | — | — | 1 | 6.89 |
| CHEMBL220364 | — | — | 1 | 6.79 |
| CHEMBL374577 | — | — | 1 | 6.77 |
| CHEMBL220989 | — | — | 1 | 6.69 |
| CHEMBL376199 | — | — | 1 | 6.65 |
| CHEMBL220417 | — | — | 1 | 6.64 |
| CHEMBL374282 | — | — | 1 | 6.61 |
| CHEMBL220435 | — | — | 1 | 6.60 |
| CHEMBL376895 | — | — | 1 | 6.48 |
| CHEMBL220941 | — | — | 1 | 6.39 |
| CHEMBL220253 | — | — | 1 | 6.30 |
| CHEMBL220416 | — | — | 1 | 6.28 |
| CHEMBL116641 | — | — | 1 | 6.10 |
| CHEMBL220010 | — | — | 1 | 6.05 |
| CHEMBL220176 | — | — | 1 | 6.04 |
| CHEMBL374894 | — | — | 1 | 6.01 |
| CHEMBL220434 | — | — | 1 | 6.00 |
| CHEMBL220311 | — | — | 1 | 5.94 |
| CHEMBL221337 | — | — | 1 | 5.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL219777 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL375521 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL219611 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL425291 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL220996 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL219618 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL374479 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL219612 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL376198 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL331784 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL113827 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL220389 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL220364 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL374577 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL220989 | — | IC50 | = | 206.0 | nM | 6.69 |
| CHEMBL376199 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL220417 | — | IC50 | = | 231.0 | nM | 6.64 |
| CHEMBL374282 | — | IC50 | = | 248.0 | nM | 6.61 |
| CHEMBL220435 | — | IC50 | = | 253.0 | nM | 6.60 |
| CHEMBL376895 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL220941 | — | IC50 | = | 406.0 | nM | 6.39 |
| CHEMBL220253 | — | IC50 | = | 495.0 | nM | 6.30 |
| CHEMBL220416 | — | IC50 | = | 527.0 | nM | 6.28 |
| CHEMBL116641 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL220010 | — | IC50 | = | 885.0 | nM | 6.05 |
| CHEMBL220176 | — | IC50 | = | 904.0 | nM | 6.04 |
| CHEMBL374894 | — | IC50 | = | 966.0 | nM | 6.01 |
| CHEMBL220434 | — | IC50 | = | 1011.0 | nM | 6.00 |
| CHEMBL220311 | — | IC50 | = | 1149.0 | nM | 5.94 |
| CHEMBL221337 | — | IC50 | = | 1168.0 | nM | 5.93 |
| CHEMBL220420 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL387379 | — | IC50 | = | 1931.0 | nM | 5.71 |
| CHEMBL219959 | — | IC50 | = | 2515.0 | nM | 5.60 |
| CHEMBL442042 | — | IC50 | = | 3896.0 | nM | 5.41 |
| CHEMBL219725 | — | IC50 | = | 5363.0 | nM | 5.27 |
| CHEMBL219938 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL220363 | — | IC50 | > | 10000.0 | nM | - |