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Assay Detail

CHEMBL915937

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human HL60 (TB) cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type HL-60
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

ADMET (CHEMBL612558)
Type ADMET

Publication

Design, synthesis and cytotoxic properties of novel 1-[4-(2-alkylaminoethoxy)phenylcarbonyl]-3,5-bis(arylidene)-4-piperidones and related compounds.
Das U, Alcorn J, Shrivastav A, Sharma RK, De Clercq E, Balzarini J, Dimmock JR.
Eur J Med Chem (2007) 42 : 71 -80
PubMed 16996657 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.55 6.44

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL154716 1 6.44
CHEMBL464670 1 6.25
CHEMBL499648 1 6.03
CHEMBL455005 1 5.96
CHEMBL540960 1 5.88
CHEMBL463639 1 5.85
CHEMBL852 MELPHALAN 4.0 1 5.69
CHEMBL503999 1 5.26
CHEMBL228210 1 4.93
CHEMBL455550 1 4.69
CHEMBL185 FLUOROURACIL 4.0 1 4.07
CHEMBL227188 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL154716 IC50 = 363.0 nM 6.44
CHEMBL464670 IC50 = 562.0 nM 6.25
CHEMBL499648 IC50 = 933.0 nM 6.03
CHEMBL455005 IC50 = 1100.0 nM 5.96
CHEMBL540960 IC50 = 1320.0 nM 5.88
CHEMBL463639 IC50 = 1410.0 nM 5.85
CHEMBL852 MELPHALAN IC50 = 2040.0 nM 5.69
CHEMBL503999 IC50 = 5500.0 nM 5.26
CHEMBL228210 IC50 = 11800.0 nM 4.93
CHEMBL455550 IC50 = 20400.0 nM 4.69
CHEMBL185 FLUOROURACIL IC50 = 85100.0 nM 4.07
CHEMBL227188 IC50 > 50100.0 nM -