Assay Detail
ADMET
CHEMBL915938
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Cytotoxicity against human SR cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | SR |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and cytotoxic properties of novel 1-[4-(2-alkylaminoethoxy)phenylcarbonyl]-3,5-bis(arylidene)-4-piperidones and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.68 | 6.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL463639 | — | — | 1 | 6.90 |
| CHEMBL154716 | — | — | 1 | 6.68 |
| CHEMBL455005 | — | — | 1 | 6.61 |
| CHEMBL540960 | — | — | 1 | 6.32 |
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 5.73 |
| CHEMBL455550 | — | — | 1 | 5.64 |
| CHEMBL228210 | — | — | 1 | 4.64 |
| CHEMBL227188 | — | — | 1 | 4.42 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL463639 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL154716 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL455005 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL540960 | — | IC50 | = | 479.0 | nM | 6.32 |
| CHEMBL852 | MELPHALAN | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL455550 | — | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL228210 | — | IC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL227188 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 60300.0 | nM | 4.22 |