Assay Detail
Functional
CHEMBL916228
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of hypoxia induced HIF1 transcriptional activity in human Hep3B cells by cell-based HRE reporter assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Hep 3B2 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha (CHEMBL2221345) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
(Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 5.13 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223862 | — | — | 1 | 6.40 |
| CHEMBL427092 | — | — | 1 | 5.58 |
| CHEMBL222606 | — | — | 1 | 5.37 |
| CHEMBL219673 | — | — | 1 | 5.30 |
| CHEMBL221659 | — | — | 1 | 5.14 |
| CHEMBL224964 | — | — | 1 | 5.09 |
| CHEMBL373396 | — | — | 1 | 5.00 |
| CHEMBL222873 | — | — | 1 | 4.98 |
| CHEMBL374484 | — | — | 1 | 4.90 |
| CHEMBL333985 | — | — | 1 | 4.86 |
| CHEMBL373657 | — | — | 1 | 4.85 |
| CHEMBL222637 | — | — | 1 | 4.63 |
| CHEMBL223235 | — | — | 1 | 4.54 |
| CHEMBL415056 | — | — | 1 | - |
| CHEMBL222089 | — | — | 1 | - |
| CHEMBL374776 | — | — | 1 | - |
| CHEMBL223154 | — | — | 1 | - |
| CHEMBL373912 | — | — | 1 | - |
| CHEMBL221560 | — | — | 1 | - |
| CHEMBL222422 | — | — | 1 | - |
| CHEMBL376203 | — | — | 1 | - |
| CHEMBL222657 | — | — | 1 | - |
| CHEMBL222607 | — | — | 1 | - |
| CHEMBL375173 | — | — | 1 | - |
| CHEMBL223305 | — | — | 1 | - |
| CHEMBL222754 | — | — | 1 | - |
| CHEMBL222582 | — | — | 1 | - |
| CHEMBL374969 | — | — | 1 | - |
| CHEMBL223479 | — | — | 1 | - |
| CHEMBL222251 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223862 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL427092 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL222606 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL219673 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL221659 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL224964 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL373396 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL222873 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL374484 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL333985 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL373657 | — | IC50 | = | 14080.0 | nM | 4.85 |
| CHEMBL222637 | — | IC50 | = | 23200.0 | nM | 4.63 |
| CHEMBL223235 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL222104 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL222879 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL224750 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL415056 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL222089 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL374776 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL223154 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL373912 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL221560 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL222422 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL376203 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL222657 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL222607 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL375173 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL223305 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL222754 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL222582 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL374969 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL223479 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL222251 | — | IC50 | > | 30000.0 | nM | - |