Assay Detail
Binding
CHEMBL916290
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]CGP-39653 from rat brain NMDA receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Design, synthesis, and pharmacological characterization of novel, potent NMDA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.81 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370566 | — | — | 1 | 6.68 |
| CHEMBL421402 | — | — | 1 | 6.43 |
| CHEMBL370985 | — | — | 1 | 6.02 |
| CHEMBL223663 | — | — | 1 | 4.10 |
| CHEMBL223662 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370566 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL421402 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL370985 | — | Ki | = | 960.0 | nM | 6.02 |
| CHEMBL223663 | — | Ki | = | 79000.0 | nM | 4.10 |
| CHEMBL223662 | — | Ki | > | 100000.0 | nM | - |