Assay Detail
Binding
CHEMBL916319
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Displacement of [125I]4-(3-iodoanilino)-6,7-dimethoxyquinazoline from EGFR tyrosine kinase in human A431 cell membranes
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Anilinodialkoxyquinazolines: screening epidermal growth factor receptor tyrosine kinase inhibitors for potential tumor imaging probes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 8.26 | 9.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2447950 | — | — | 1 | 9.42 |
| CHEMBL1204199 | — | — | 1 | 9.39 |
| CHEMBL1204262 | — | — | 1 | 9.19 |
| CHEMBL1204168 | — | — | 1 | 9.18 |
| CHEMBL1204305 | — | — | 1 | 8.98 |
| CHEMBL540068 | — | — | 1 | 8.90 |
| CHEMBL1204261 | — | — | 1 | 8.09 |
| CHEMBL1203935 | — | — | 1 | 8.05 |
| CHEMBL1203939 | — | — | 1 | 8.03 |
| CHEMBL1203940 | — | — | 1 | 7.80 |
| CHEMBL1203937 | — | — | 1 | 7.77 |
| CHEMBL1203936 | — | — | 1 | 7.70 |
| CHEMBL541586 | — | — | 1 | 7.50 |
| CHEMBL1204360 | — | — | 1 | 7.49 |
| CHEMBL1203938 | — | — | 1 | 7.32 |
| CHEMBL1203934 | — | — | 1 | 7.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2447950 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL1204199 | — | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL1204262 | — | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL1204168 | — | IC50 | = | 0.66 | nM | 9.18 |
| CHEMBL1204305 | — | IC50 | = | 1.05 | nM | 8.98 |
| CHEMBL540068 | — | IC50 | = | 1.26 | nM | 8.90 |
| CHEMBL1204261 | — | IC50 | = | 8.17 | nM | 8.09 |
| CHEMBL1203935 | — | IC50 | = | 8.95 | nM | 8.05 |
| CHEMBL1203939 | — | IC50 | = | 9.31 | nM | 8.03 |
| CHEMBL1203940 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1203937 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1203936 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL541586 | — | IC50 | = | 31.9 | nM | 7.50 |
| CHEMBL1204360 | — | IC50 | = | 32.2 | nM | 7.49 |
| CHEMBL1203938 | — | IC50 | = | 47.7 | nM | 7.32 |
| CHEMBL1203934 | — | IC50 | = | 51.0 | nM | 7.29 |