Assay Detail
Functional
CHEMBL916320
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human EGFR tyrosine kinase phosphorylation expressed in mouse BaF3 cells
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BaF3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Anilinodialkoxyquinazolines: screening epidermal growth factor receptor tyrosine kinase inhibitors for potential tumor imaging probes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 8.20 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL540068 | — | — | 1 | 9.10 |
| CHEMBL2447950 | — | — | 1 | 8.92 |
| CHEMBL1204168 | — | — | 1 | 8.59 |
| CHEMBL1204199 | — | — | 1 | 8.49 |
| CHEMBL1204262 | — | — | 1 | 8.34 |
| CHEMBL541586 | — | — | 1 | 8.20 |
| CHEMBL1204261 | — | — | 1 | 8.19 |
| CHEMBL1204305 | — | — | 1 | 8.19 |
| CHEMBL1203937 | — | — | 1 | 8.18 |
| CHEMBL1203938 | — | — | 1 | 7.96 |
| CHEMBL1204360 | — | — | 1 | 7.89 |
| CHEMBL1203939 | — | — | 1 | 7.80 |
| CHEMBL1203934 | — | — | 1 | 7.72 |
| CHEMBL1203936 | — | — | 1 | 7.72 |
| CHEMBL1203940 | — | — | 1 | 7.64 |
| CHEMBL1203935 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL540068 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL2447950 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1204168 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL1204199 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL1204262 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL541586 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL1204261 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL1204305 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL1203937 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL1203938 | — | IC50 | = | 10.9 | nM | 7.96 |
| CHEMBL1204360 | — | IC50 | = | 12.8 | nM | 7.89 |
| CHEMBL1203939 | — | IC50 | = | 15.8 | nM | 7.80 |
| CHEMBL1203934 | — | IC50 | = | 19.1 | nM | 7.72 |
| CHEMBL1203936 | — | IC50 | = | 19.1 | nM | 7.72 |
| CHEMBL1203940 | — | IC50 | = | 23.1 | nM | 7.64 |
| CHEMBL1203935 | — | IC50 | > | 50.0 | nM | - |