Assay Detail
Functional
CHEMBL916378
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ATRA-induced CYP26 in human T47D cells assessed as ATRA metabolism using [11.12-3H]-ATRA
18
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel retinoic acid metabolism blocking agents endowed with multiple biological activities are efficient growth inhibitors of human breast and prostate cancer cells in vitro and a human breast tumor xenograft in nude mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.82 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57765 | — | — | 1 | 8.20 |
| CHEMBL223072 | — | — | 1 | 8.00 |
| CHEMBL190837 | — | — | 1 | 7.62 |
| CHEMBL224828 | — | — | 1 | 6.67 |
| CHEMBL225621 | — | — | 2 | 5.22 |
| CHEMBL431135 | — | — | 1 | - |
| CHEMBL224080 | — | — | 1 | - |
| CHEMBL7301 | FENRETINIDE | 3.0 | 1 | - |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | - |
| CHEMBL225121 | — | — | 1 | - |
| CHEMBL225429 | — | — | 1 | - |
| CHEMBL387639 | — | — | 1 | - |
| CHEMBL224995 | — | — | 1 | - |
| CHEMBL388283 | — | — | 1 | - |
| CHEMBL388064 | — | — | 1 | - |
| CHEMBL53449 | — | — | 1 | - |
| CHEMBL417769 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57765 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL223072 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL190837 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL224828 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL225621 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL225621 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL431135 | — | IC50 | - | — | - | |
| CHEMBL224080 | — | IC50 | - | — | - | |
| CHEMBL7301 | FENRETINIDE | IC50 | - | — | - | |
| CHEMBL157101 | KETOCONAZOLE | IC50 | - | — | - | |
| CHEMBL225121 | — | IC50 | - | — | - | |
| CHEMBL225429 | — | IC50 | - | — | - | |
| CHEMBL387639 | — | IC50 | - | — | - | |
| CHEMBL224995 | — | IC50 | - | — | - | |
| CHEMBL388283 | — | IC50 | - | — | - | |
| CHEMBL388064 | — | IC50 | - | — | - | |
| CHEMBL53449 | — | IC50 | - | — | - | |
| CHEMBL417769 | — | IC50 | - | — | - |