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Assay Detail

CHEMBL916472

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human CEM cells after 72 hrs by MTT assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type CCRF-CEM
Confidence 1 — Organism
Curated By Autocuration

Target

CCRF-CEM (CHEMBL382)
Type CELL-LINE
Organism Homo sapiens

Publication

Triterpenoid pyrazines and benzopyrazines with cytotoxic activity.
Urban M, Sarek J, Kvasnica M, Tislerova I, Hajduch M.
J Nat Prod (2007) 70 : 526 -532
PubMed 17371067 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 35 4.79 5.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL296567 DIHYDROBETULONIC ACID 1 5.70
CHEMBL108505 DIHYDROBETULINIC ACID 1 5.16
CHEMBL222760 1 5.10
CHEMBL376049 1 4.92
CHEMBL221890 1 4.85
CHEMBL153117 1 4.80
CHEMBL431525 BETUNOLIC ACID 1 4.70
CHEMBL269277 BETULINIC ACID 1.0 1 4.52
CHEMBL222526 1 4.46
CHEMBL222651 1 4.38
CHEMBL224818 1 4.13
CHEMBL376864 1 -
CHEMBL222479 1 -
CHEMBL222586 1 -
CHEMBL222428 1 -
CHEMBL387323 1 -
CHEMBL267420 1 -
CHEMBL221422 1 -
CHEMBL376208 1 -
CHEMBL345734 1 -
CHEMBL221836 1 -
CHEMBL221835 ALLOBETULONE 1 -
CHEMBL496855 ALLOBETULIN 1 -
CHEMBL387150 METHYL DIHYDROBETULONATE 1 -
CHEMBL376483 1 -
CHEMBL373633 1 -
CHEMBL23236 BETULIN 1 -
CHEMBL376266 METHYL BETULONATE 1 -
CHEMBL374317 1 -
CHEMBL222239 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL296567 DIHYDROBETULONIC ACID IC50 = 2000.0 nM 5.70
CHEMBL108505 DIHYDROBETULINIC ACID IC50 = 7000.0 nM 5.16
CHEMBL222760 IC50 = 8000.0 nM 5.10
CHEMBL376049 IC50 = 12000.0 nM 4.92
CHEMBL221890 IC50 = 14000.0 nM 4.85
CHEMBL153117 IC50 = 16000.0 nM 4.80
CHEMBL431525 BETUNOLIC ACID IC50 = 20000.0 nM 4.70
CHEMBL269277 BETULINIC ACID IC50 = 30000.0 nM 4.52
CHEMBL222526 IC50 = 35000.0 nM 4.46
CHEMBL222651 IC50 = 42000.0 nM 4.38
CHEMBL224818 IC50 = 74000.0 nM 4.13
CHEMBL221422 IC50 = 244000.0 nM -
CHEMBL267420 IC50 = 232000.0 nM -
CHEMBL387323 IC50 = 106000.0 nM -
CHEMBL222428 IC50 = 215000.0 nM -
CHEMBL222586 IC50 = 151000.0 nM -
CHEMBL222479 IC50 = 178000.0 nM -
CHEMBL376864 IC50 = 250000.0 nM -
CHEMBL222652 IC50 = 124000.0 nM -
CHEMBL374870 IC50 = 250000.0 nM -
CHEMBL221372 IC50 = 250000.0 nM -
CHEMBL375234 IC50 = 250000.0 nM -
CHEMBL222703 IC50 = 101000.0 nM -
CHEMBL376208 IC50 = 250000.0 nM -
CHEMBL345734 IC50 = 250000.0 nM -
CHEMBL221836 IC50 = 250000.0 nM -
CHEMBL221835 ALLOBETULONE IC50 = 250000.0 nM -
CHEMBL496855 ALLOBETULIN IC50 = 250000.0 nM -
CHEMBL387150 METHYL DIHYDROBETULONATE IC50 = 173000.0 nM -
CHEMBL376483 IC50 = 192000.0 nM -
CHEMBL373633 IC50 = 250000.0 nM -
CHEMBL23236 BETULIN IC50 = 250000.0 nM -
CHEMBL376266 METHYL BETULONATE IC50 = 250000.0 nM -
CHEMBL374317 IC50 = 250000.0 nM -
CHEMBL222239 IC50 = 250000.0 nM -