Assay Detail
ADMET
CHEMBL916476
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Cytotoxicity against human Pgp-positive multidrug-resistant K562-tax cells after 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | K562-tax |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Triterpenoid pyrazines and benzopyrazines with cytotoxic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.80 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222760 | — | — | 1 | 5.40 |
| CHEMBL221890 | — | — | 1 | 5.10 |
| CHEMBL153117 | — | — | 1 | 5.05 |
| CHEMBL431525 | BETUNOLIC ACID | — | 1 | 4.77 |
| CHEMBL376049 | — | — | 1 | 4.46 |
| CHEMBL222586 | — | — | 1 | 4.04 |
| CHEMBL387323 | — | — | 1 | - |
| CHEMBL222652 | — | — | 1 | - |
| CHEMBL376864 | — | — | 1 | - |
| CHEMBL222651 | — | — | 1 | - |
| CHEMBL267420 | — | — | 1 | - |
| CHEMBL345734 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222760 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL221890 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL153117 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL431525 | BETUNOLIC ACID | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL376049 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL222586 | — | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL387323 | — | IC50 | = | 234000.0 | nM | - |
| CHEMBL222652 | — | IC50 | = | 117000.0 | nM | - |
| CHEMBL376864 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL222651 | — | IC50 | = | 118000.0 | nM | - |
| CHEMBL267420 | — | IC50 | = | 149000.0 | nM | - |
| CHEMBL345734 | — | IC50 | = | 250000.0 | nM | - |