Assay Detail
ADMET
CHEMBL916478
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Cytotoxicity against human SK-MEL-2 cells after 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | SK-MEL-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Triterpenoid pyrazines and benzopyrazines with cytotoxic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.40 | 4.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL153117 | — | — | 1 | 4.85 |
| CHEMBL431525 | BETUNOLIC ACID | — | 1 | 4.58 |
| CHEMBL376049 | — | — | 1 | 4.16 |
| CHEMBL221890 | — | — | 1 | 4.01 |
| CHEMBL387323 | — | — | 1 | - |
| CHEMBL222651 | — | — | 1 | - |
| CHEMBL267420 | — | — | 1 | - |
| CHEMBL345734 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL153117 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL431525 | BETUNOLIC ACID | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL376049 | — | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL221890 | — | IC50 | = | 98000.0 | nM | 4.01 |
| CHEMBL387323 | — | IC50 | = | 231000.0 | nM | - |
| CHEMBL222651 | — | IC50 | = | 192000.0 | nM | - |
| CHEMBL267420 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL345734 | — | IC50 | = | 170000.0 | nM | - |