Assay Detail
Functional
CHEMBL916519
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Inhibition of LPS-induced BALB/c mouse B cell proliferation
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | B-cell |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.36 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 6.80 |
| CHEMBL390369 | NORARISTOLODIONE | — | 1 | 6.51 |
| CHEMBL441882 | OXOCALYCININE | — | 1 | 6.25 |
| CHEMBL387864 | PIPEROLACTAM A | — | 1 | 5.89 |
| CHEMBL227479 | — | — | 1 | 5.77 |
| CHEMBL390715 | ARISTOLACTAM BIII | — | 1 | 5.70 |
| CHEMBL390615 | OXODISCOGUATTINE | — | 1 | 5.67 |
| CHEMBL226824 | CALYCININE | — | 1 | 5.53 |
| CHEMBL224744 | — | — | 1 | 5.40 |
| CHEMBL226655 | ARISTOLACTAM F II | — | 1 | 5.40 |
| CHEMBL227962 | DUGUEVANINE | — | 1 | 5.26 |
| CHEMBL227414 | NORCEPHARADIONE | — | 1 | 5.17 |
| CHEMBL226772 | CEPHARANONE B | — | 1 | 5.15 |
| CHEMBL389400 | ATHEROSPERMIDINE | — | 1 | 5.14 |
| CHEMBL227689 | XYLOPINE | — | 1 | 5.09 |
| CHEMBL388956 | ARISTOLACTAM AIIIA | — | 1 | 4.72 |
| CHEMBL227965 | CORYTUBERINE | — | 1 | 4.67 |
| CHEMBL462880 | ISOBOLDINE | — | 1 | 4.53 |
| CHEMBL412823 | OLDHAMACTAM | — | 1 | 4.38 |
| CHEMBL389271 | ASIMILOBINE | — | 1 | 4.10 |
| CHEMBL390368 | ARISTOLACTAM AII | — | 1 | - |
| CHEMBL228081 | GONIOTHALACTAM | — | 1 | - |
| CHEMBL389270 | ISOLAURELINE | — | 1 | - |
| CHEMBL604339 | CREBANINE | — | 1 | - |
| CHEMBL227533 | HOMOMOSCHATOLINE | — | 1 | - |
| CHEMBL228082 | GLAUCINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL390369 | NORARISTOLODIONE | IC50 | = | 312.0 | nM | 6.51 |
| CHEMBL441882 | OXOCALYCININE | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL387864 | PIPEROLACTAM A | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL227479 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL390715 | ARISTOLACTAM BIII | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL390615 | OXODISCOGUATTINE | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL226824 | CALYCININE | IC50 | = | 2930.0 | nM | 5.53 |
| CHEMBL224744 | — | IC50 | = | 3970.0 | nM | 5.40 |
| CHEMBL226655 | ARISTOLACTAM F II | IC50 | = | 3960.0 | nM | 5.40 |
| CHEMBL227962 | DUGUEVANINE | IC50 | = | 5540.0 | nM | 5.26 |
| CHEMBL227414 | NORCEPHARADIONE | IC50 | = | 6720.0 | nM | 5.17 |
| CHEMBL226772 | CEPHARANONE B | IC50 | = | 7110.0 | nM | 5.15 |
| CHEMBL389400 | ATHEROSPERMIDINE | IC50 | = | 7290.0 | nM | 5.14 |
| CHEMBL227689 | XYLOPINE | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL388956 | ARISTOLACTAM AIIIA | IC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL227965 | CORYTUBERINE | IC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL462880 | ISOBOLDINE | IC50 | = | 29600.0 | nM | 4.53 |
| CHEMBL412823 | OLDHAMACTAM | IC50 | = | 41700.0 | nM | 4.38 |
| CHEMBL389271 | ASIMILOBINE | IC50 | = | 79600.0 | nM | 4.10 |
| CHEMBL390368 | ARISTOLACTAM AII | IC50 | > | 100000.0 | nM | - |
| CHEMBL228081 | GONIOTHALACTAM | IC50 | > | 100000.0 | nM | - |
| CHEMBL389270 | ISOLAURELINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL604339 | CREBANINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL227533 | HOMOMOSCHATOLINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL228082 | GLAUCINE | IC50 | > | 100000.0 | nM | - |