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Compound Detail

CHEMBL389400

ATHEROSPERMIDINE
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COc1ccc2c(c1)C(=O)c1nccc3cc4c(c-2c13)OCO4

Basic Information

ChEMBL ID CHEMBL389400
Name ATHEROSPERMIDINE
Phase Preclinical
Structure Type MOL
InChI Key WLXLLQQGGGHOMA-UHFFFAOYSA-N
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
16
Publications
0
Known Names

Molecular Properties

305.3
MW (Da)
3.18
ALogP
5
HBA
0
HBD
57.6
PSA (Ų)
0.54
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C18H11NO4
MW 305.29
Aromatic Rings 3
Heavy Atoms 23
NP-Likeness 1.07

Activity Summary

IC50 5 meas. best 5.38

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
T-cell
CHEMBL614309
IC50 5.38 5.38 4160.0 1
Molecular identity unknown
CHEMBL612546
IC50 5.15 5.15 7100.0 1
B-cell
CHEMBL614701
IC50 5.14 5.14 7290.0 1
Acetylcholinesterase
CHEMBL220
IC50 4.96 4.96 10900.0 1
Amyloid-beta precursor protein
CHEMBL2487
IC50 4.5 4.5 31900.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

Data from ChEMBL 36 via Core Engine