Assay Detail
Binding
CHEMBL3868882
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Wnt signalling in human STF/293 cells assessed as suppression of TCF/beta-catenin-mediated transcriptional activity after 24 hrs by superTOPflash reporter gene assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | STF/293 |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Cerasoidine, a Bis-aporphine Alkaloid Isolated from Polyalthia cerasoides during Screening for Wnt Signal Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.47 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL37736 | LIRIODENINE | — | 1 | 6.22 |
| CHEMBL3950972 | — | — | 1 | 6.22 |
| CHEMBL389400 | ATHEROSPERMIDINE | — | 1 | 5.15 |
| CHEMBL3924309 | — | — | 1 | 5.06 |
| CHEMBL400245 | BIDEBILINE E | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL37736 | LIRIODENINE | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3950972 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL389400 | ATHEROSPERMIDINE | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL3924309 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL400245 | BIDEBILINE E | IC50 | = | 20200.0 | nM | 4.70 |