Assay Detail
Functional
CHEMBL916518
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Inhibition of ConA-induced BALB/c mouse T cell proliferation
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | T-cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.39 | 8.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 8.86 |
| CHEMBL387864 | PIPEROLACTAM A | — | 1 | 6.10 |
| CHEMBL227414 | NORCEPHARADIONE | — | 1 | 6.10 |
| CHEMBL441882 | OXOCALYCININE | — | 1 | 6.09 |
| CHEMBL390715 | ARISTOLACTAM BIII | — | 1 | 5.64 |
| CHEMBL227479 | — | — | 1 | 5.61 |
| CHEMBL390615 | OXODISCOGUATTINE | — | 1 | 5.45 |
| CHEMBL389400 | ATHEROSPERMIDINE | — | 1 | 5.38 |
| CHEMBL226824 | CALYCININE | — | 1 | 5.31 |
| CHEMBL390369 | NORARISTOLODIONE | — | 1 | 5.31 |
| CHEMBL227689 | XYLOPINE | — | 1 | 5.25 |
| CHEMBL226772 | CEPHARANONE B | — | 1 | 5.16 |
| CHEMBL227962 | DUGUEVANINE | — | 1 | 5.16 |
| CHEMBL226655 | ARISTOLACTAM F II | — | 1 | 5.00 |
| CHEMBL388956 | ARISTOLACTAM AIIIA | — | 1 | 4.73 |
| CHEMBL412823 | OLDHAMACTAM | — | 1 | 4.64 |
| CHEMBL227965 | CORYTUBERINE | — | 1 | 4.63 |
| CHEMBL462880 | ISOBOLDINE | — | 1 | 4.62 |
| CHEMBL224744 | — | — | 1 | 4.41 |
| CHEMBL389271 | ASIMILOBINE | — | 1 | 4.35 |
| CHEMBL390368 | ARISTOLACTAM AII | — | 1 | - |
| CHEMBL389270 | ISOLAURELINE | — | 1 | - |
| CHEMBL604339 | CREBANINE | — | 1 | - |
| CHEMBL228081 | GONIOTHALACTAM | — | 1 | - |
| CHEMBL227533 | HOMOMOSCHATOLINE | — | 1 | - |
| CHEMBL228082 | GLAUCINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 1.37 | nM | 8.86 |
| CHEMBL387864 | PIPEROLACTAM A | IC50 | = | 798.0 | nM | 6.10 |
| CHEMBL227414 | NORCEPHARADIONE | IC50 | = | 795.0 | nM | 6.10 |
| CHEMBL441882 | OXOCALYCININE | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL390715 | ARISTOLACTAM BIII | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL227479 | — | IC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL390615 | OXODISCOGUATTINE | IC50 | = | 3580.0 | nM | 5.45 |
| CHEMBL389400 | ATHEROSPERMIDINE | IC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL226824 | CALYCININE | IC50 | = | 4860.0 | nM | 5.31 |
| CHEMBL390369 | NORARISTOLODIONE | IC50 | = | 4930.0 | nM | 5.31 |
| CHEMBL227689 | XYLOPINE | IC50 | = | 5690.0 | nM | 5.25 |
| CHEMBL226772 | CEPHARANONE B | IC50 | = | 6960.0 | nM | 5.16 |
| CHEMBL227962 | DUGUEVANINE | IC50 | = | 6860.0 | nM | 5.16 |
| CHEMBL226655 | ARISTOLACTAM F II | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL388956 | ARISTOLACTAM AIIIA | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL412823 | OLDHAMACTAM | IC50 | = | 22800.0 | nM | 4.64 |
| CHEMBL227965 | CORYTUBERINE | IC50 | = | 23200.0 | nM | 4.63 |
| CHEMBL462880 | ISOBOLDINE | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL224744 | — | IC50 | = | 39300.0 | nM | 4.41 |
| CHEMBL389271 | ASIMILOBINE | IC50 | = | 44800.0 | nM | 4.35 |
| CHEMBL390368 | ARISTOLACTAM AII | IC50 | > | 100000.0 | nM | - |
| CHEMBL389270 | ISOLAURELINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL604339 | CREBANINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL228081 | GONIOTHALACTAM | IC50 | > | 100000.0 | nM | - |
| CHEMBL227533 | HOMOMOSCHATOLINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL228082 | GLAUCINE | IC50 | > | 100000.0 | nM | - |