Assay Detail
Binding
CHEMBL916640
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Displacement of radiolabeled Dexamethasone from human GR
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Novel series of potent, nonsteroidal, selective androgen receptor modulators based on 7H-[1,4]oxazino[3,2-g]quinolin-7-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.09 | 5.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388997 | — | — | 1 | 5.19 |
| CHEMBL224204 | — | — | 1 | 5.09 |
| CHEMBL227440 | — | — | 1 | 5.07 |
| CHEMBL227784 | — | — | 1 | 5.06 |
| CHEMBL227783 | — | — | 1 | 5.04 |
| CHEMBL226609 | — | — | 1 | - |
| CHEMBL389481 | — | — | 1 | - |
| CHEMBL227408 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388997 | — | Ki | = | 6500.0 | nM | 5.19 |
| CHEMBL224204 | — | Ki | = | 8100.0 | nM | 5.09 |
| CHEMBL227440 | — | Ki | = | 8500.0 | nM | 5.07 |
| CHEMBL227784 | — | Ki | = | 8800.0 | nM | 5.06 |
| CHEMBL227783 | — | Ki | = | 9200.0 | nM | 5.04 |
| CHEMBL226609 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL389481 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL227408 | — | Ki | > | 10000.0 | nM | - |