Assay Detail
Functional
CHEMBL916789
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Antiviral activity against HIV1 BAL in human MDM cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MDM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-activity relationships in platelet-activating factor. 12. Synthesis and biological evaluation of platelet-activating factor antagonists with anti-HIV-1 activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.91 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388846 | — | — | 1 | 6.00 |
| CHEMBL269340 | — | — | 1 | 5.00 |
| CHEMBL6322 | PMS-601 | — | 1 | 4.96 |
| CHEMBL375865 | — | — | 1 | 4.60 |
| CHEMBL388847 | — | — | 1 | 4.50 |
| CHEMBL389953 | — | — | 1 | 4.40 |
| CHEMBL388845 | — | — | 1 | - |
| CHEMBL375809 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388846 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL269340 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL6322 | PMS-601 | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL375865 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL388847 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL389953 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL388845 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL375809 | — | IC50 | > | 100000.0 | nM | - |