Assay Detail
Binding
CHEMBL916999
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 15LOX in rabbit reticulocytes by EIA assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Polyunsaturated fatty acid lipoxygenase ALOX15 (CHEMBL4358) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.75 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 6.37 |
| CHEMBL227135 | — | — | 1 | 6.28 |
| CHEMBL227187 | — | — | 1 | 6.28 |
| CHEMBL436990 | — | — | 1 | 6.12 |
| CHEMBL180917 | — | — | 1 | 5.95 |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 5.66 |
| CHEMBL460862 | (-)-PINORESINOL | — | 1 | 5.46 |
| CHEMBL390320 | ISOSCOPOLETIN | — | 1 | 4.82 |
| CHEMBL71851 | SCOPOLETIN | — | 1 | 4.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50 | QUERCETIN | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL227135 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL227187 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL436990 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL180917 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL150 | KAEMPFEROL | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL460862 | (-)-PINORESINOL | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL390320 | ISOSCOPOLETIN | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL71851 | SCOPOLETIN | IC50 | = | 16500.0 | nM | 4.78 |