Assay Detail
Functional
CHEMBL917103
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Agonist activity at human recombinant P2Y6 receptor expressed in 1321N1 cells assessed as stimulation of phospholipase C
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 1321-N1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.37 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220940 | THYMIDINE_TRIPHOSPHATE | — | 1 | 6.85 |
| CHEMBL220011 | — | — | 1 | 6.48 |
| CHEMBL219779 | — | — | 1 | 6.33 |
| CHEMBL217803 | — | — | 1 | 5.82 |
| CHEMBL410594 | — | — | 1 | - |
| CHEMBL385098 | — | — | 1 | - |
| CHEMBL373780 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220940 | THYMIDINE_TRIPHOSPHATE | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL220011 | — | EC50 | = | 333.0 | nM | 6.48 |
| CHEMBL219779 | — | EC50 | = | 467.0 | nM | 6.33 |
| CHEMBL217803 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL410594 | — | EC50 | - | — | - | |
| CHEMBL385098 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL373780 | — | EC50 | > | 10000.0 | nM | - |