Assay Detail
Binding
CHEMBL917129
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human group IB PLA2 in [3H]oleate-labeled Escherichia coli membrane by radiometric assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Inhibition of secreted phospholipase A2. 4-glycerol derivatives of 4,5-dihydro-3-(4-tetradecyloxybenzyl)-1,2,4-4H-oxadiazol-5-one with broad activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.07 | 5.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL357979 | — | — | 1 | 5.48 |
| CHEMBL373999 | — | — | 1 | 5.24 |
| CHEMBL373870 | — | — | 1 | 5.12 |
| CHEMBL223880 | — | — | 1 | 5.06 |
| CHEMBL220842 | — | — | 1 | 5.00 |
| CHEMBL353623 | — | — | 1 | 4.82 |
| CHEMBL220633 | — | — | 1 | 4.75 |
| CHEMBL223233 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL357979 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL373999 | — | IC50 | = | 5750.0 | nM | 5.24 |
| CHEMBL373870 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL223880 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL220842 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL353623 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL220633 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL223233 | — | IC50 | > | 100000.0 | nM | - |