Compound Detail
CHEMBL223233
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Basic Information
| ChEMBL ID | CHEMBL223233 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YHFOQUQUEBKFBJ-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
538.7
MW (Da)
7.71
ALogP
6
HBA
1
HBD
86.6
PSA (Ų)
0.13
QED
2
Ro5 Violations
22
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Group 10 secretory phospholipase A2 CHEMBL4342 | IC50 | 4.85 | 4.85 | 14000.0 | 1 |
| Phospholipase A2, membrane associated CHEMBL3474 | IC50 | 4.83 | 4.83 | 14800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Group 10 secretory phospholipase A2 | IC50 | = | 14000.0 | nM | 4.85 | Inhibition of human group X PLA2 in [3H]oleate-labeled Escherichia coli membrane... | 17335183 |
| Phospholipase A2, membrane associated | IC50 | = | 14800.0 | nM | 4.83 | Inhibition of human group IIA PLA2 by fluorimetric assay | 17335183 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17335183 | 10.1021/jm060082n | Phospholipase A2, membrane associated | 2 |
| 17335183 | 10.1021/jm060082n | Phospholipase A2, major isoenzyme | 1 |
| 17335183 | 10.1021/jm060082n | No relevant target | 1 |
| 17335183 | 10.1021/jm060082n | Phospholipase A2 | 1 |
| 17335183 | 10.1021/jm060082n | Phospholipase A2 group V | 1 |
| 17335183 | 10.1021/jm060082n | Group 10 secretory phospholipase A2 | 1 |
Data from ChEMBL 36 via Core Engine