Assay Detail
Functional
CHEMBL917138
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Vasodilation of phenylephrine-induced contraction in Wistar rat aorta
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
NO-donor COX-2 inhibitors. New nitrooxy-substituted 1,5-diarylimidazoles endowed with COX-2 inhibitory and vasodilator properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.02 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223619 | — | — | 1 | 7.68 |
| CHEMBL219885 | — | — | 1 | 7.68 |
| CHEMBL223529 | — | — | 1 | 7.29 |
| CHEMBL373819 | — | — | 1 | 7.11 |
| CHEMBL376246 | — | — | 1 | 7.00 |
| CHEMBL6622 | ISOSORBIDE DINITRATE | 4.0 | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223619 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL219885 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL223529 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL373819 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL376246 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL6622 | ISOSORBIDE DINITRATE | EC50 | = | 4700.0 | nM | 5.33 |