Assay Detail
Binding
CHEMBL917209
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Inhibition of human recombinant AChE
23
Total Activities
19
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.15 | 8.48 |
| Ki | 4 | 7.71 | 8.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222946 | — | — | 1 | 8.48 |
| CHEMBL222904 | — | — | 2 | 8.48 |
| CHEMBL19949 | — | — | 1 | 8.24 |
| CHEMBL221992 | — | — | 1 | 8.24 |
| CHEMBL222378 | — | — | 1 | 8.18 |
| CHEMBL387394 | — | — | 1 | 8.13 |
| CHEMBL385130 | — | — | 2 | 7.91 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 7.87 |
| CHEMBL502 | DONEPEZIL | 4.0 | 2 | 7.69 |
| CHEMBL222340 | — | — | 1 | 7.44 |
| CHEMBL222818 | — | — | 1 | 7.20 |
| CHEMBL222856 | — | — | 2 | 6.98 |
| CHEMBL222043 | — | — | 1 | 6.92 |
| CHEMBL222875 | — | — | 1 | 6.77 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.37 |
| CHEMBL222037 | — | — | 1 | 5.97 |
| CHEMBL222044 | — | — | 1 | 5.58 |
| CHEMBL500996 | METHOCTRAMINE HYDROCHLORIDE | — | 1 | 5.27 |
| CHEMBL611732 | — | — | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222946 | — | IC50 | = | 3.311 | nM | 8.48 |
| CHEMBL222904 | — | IC50 | = | 3.311 | nM | 8.48 |
| CHEMBL222904 | — | Ki | = | 5.67 | nM | 8.25 |
| CHEMBL221992 | — | IC50 | = | 5.754 | nM | 8.24 |
| CHEMBL19949 | — | IC50 | = | 5.754 | nM | 8.24 |
| CHEMBL222378 | — | IC50 | = | 6.607 | nM | 8.18 |
| CHEMBL387394 | — | IC50 | = | 7.413 | nM | 8.13 |
| CHEMBL385130 | — | Ki | = | 12.2 | nM | 7.91 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 13.49 | nM | 7.87 |
| CHEMBL385130 | — | IC50 | = | 18.62 | nM | 7.73 |
| CHEMBL502 | DONEPEZIL | Ki | = | 20.5 | nM | 7.69 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 22.91 | nM | 7.64 |
| CHEMBL222340 | — | IC50 | = | 36.31 | nM | 7.44 |
| CHEMBL222818 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL222856 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL222043 | — | IC50 | = | 120.23 | nM | 6.92 |
| CHEMBL222875 | — | IC50 | = | 169.82 | nM | 6.77 |
| CHEMBL222856 | — | IC50 | = | 169.82 | nM | 6.77 |
| CHEMBL95 | TACRINE | IC50 | = | 426.58 | nM | 6.37 |
| CHEMBL222037 | — | IC50 | = | 1071.52 | nM | 5.97 |
| CHEMBL222044 | — | IC50 | = | 2630.27 | nM | 5.58 |
| CHEMBL500996 | METHOCTRAMINE HYDROCHLORIDE | IC50 | = | 5370.32 | nM | 5.27 |
| CHEMBL611732 | — | IC50 | = | 30902.95 | nM | 4.51 |