Assay Detail
Binding
CHEMBL917210
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Inhibition of human recombinant BChE
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.66 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 7.58 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.34 |
| CHEMBL221992 | — | — | 1 | 6.18 |
| CHEMBL500996 | METHOCTRAMINE HYDROCHLORIDE | — | 1 | 6.01 |
| CHEMBL222043 | — | — | 1 | 5.96 |
| CHEMBL222037 | — | — | 1 | 5.79 |
| CHEMBL222875 | — | — | 1 | 5.77 |
| CHEMBL222818 | — | — | 1 | 5.74 |
| CHEMBL222340 | — | — | 1 | 5.73 |
| CHEMBL19949 | — | — | 1 | 5.73 |
| CHEMBL385130 | — | — | 1 | 5.65 |
| CHEMBL222378 | — | — | 1 | 5.47 |
| CHEMBL387394 | — | — | 1 | 5.44 |
| CHEMBL222946 | — | — | 1 | 5.19 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 5.12 |
| CHEMBL222904 | — | — | 1 | 5.07 |
| CHEMBL222856 | — | — | 1 | 4.93 |
| CHEMBL222044 | — | — | 1 | 4.81 |
| CHEMBL611732 | — | — | 1 | 4.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 26.3 | nM | 7.58 |
| CHEMBL95 | TACRINE | IC50 | = | 45.71 | nM | 7.34 |
| CHEMBL221992 | — | IC50 | = | 660.69 | nM | 6.18 |
| CHEMBL500996 | METHOCTRAMINE HYDROCHLORIDE | IC50 | = | 977.24 | nM | 6.01 |
| CHEMBL222043 | — | IC50 | = | 1096.48 | nM | 5.96 |
| CHEMBL222037 | — | IC50 | = | 1621.81 | nM | 5.79 |
| CHEMBL222875 | — | IC50 | = | 1698.24 | nM | 5.77 |
| CHEMBL222818 | — | IC50 | = | 1819.7 | nM | 5.74 |
| CHEMBL222340 | — | IC50 | = | 1862.09 | nM | 5.73 |
| CHEMBL19949 | — | IC50 | = | 1862.09 | nM | 5.73 |
| CHEMBL385130 | — | IC50 | = | 2238.72 | nM | 5.65 |
| CHEMBL222378 | — | IC50 | = | 3388.44 | nM | 5.47 |
| CHEMBL387394 | — | IC50 | = | 3630.78 | nM | 5.44 |
| CHEMBL222946 | — | IC50 | = | 6456.54 | nM | 5.19 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 7585.78 | nM | 5.12 |
| CHEMBL222904 | — | IC50 | = | 8511.38 | nM | 5.07 |
| CHEMBL222856 | — | IC50 | = | 11748.98 | nM | 4.93 |
| CHEMBL222044 | — | IC50 | = | 15488.17 | nM | 4.81 |
| CHEMBL611732 | — | IC50 | = | 95499.26 | nM | 4.02 |