Assay Detail
Functional
CHEMBL917430
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human muscarinic M3 receptor expressed in CHO cells
5
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Dioxane and oxathiane nuclei: suitable substructures for muscarinic agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.45 | 6.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL228144 | — | — | 2 | 6.56 |
| CHEMBL390842 | — | — | 1 | 6.39 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 5.74 |
| CHEMBL227378 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL228144 | — | EC50 | = | 275.42 | nM | 6.56 |
| CHEMBL390842 | — | EC50 | = | 407.38 | nM | 6.39 |
| CHEMBL14 | CARBACHOL | EC50 | = | 1819.7 | nM | 5.74 |
| CHEMBL227378 | — | EC50 | = | 50118.72 | nM | 4.30 |
| CHEMBL228144 | — | EC50 | = | 56234.13 | nM | 4.25 |