Assay Detail
ADMET
CHEMBL917814
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Cytotoxicity against human SNU638 cells after 3 days by SRB assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | SNU-638 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis of 6-chloroisoquinoline-5,8-diones and pyrido[3,4-b]phenazine-5,12-diones and evaluation of their cytotoxicity and DNA topoisomerase II inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.10 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL224767 | — | — | 1 | 6.92 |
| CHEMBL375931 | — | — | 1 | 6.58 |
| CHEMBL224724 | — | — | 1 | 6.46 |
| CHEMBL11269 | — | — | 1 | 6.31 |
| CHEMBL224181 | — | — | 1 | 6.22 |
| CHEMBL224647 | — | — | 1 | 6.17 |
| CHEMBL223961 | — | — | 1 | 6.15 |
| CHEMBL224254 | — | — | 1 | 6.03 |
| CHEMBL223818 | — | — | 1 | 5.97 |
| CHEMBL224794 | — | — | 1 | 5.97 |
| CHEMBL387701 | — | — | 1 | 5.97 |
| CHEMBL224682 | — | — | 1 | 5.91 |
| CHEMBL11645 | — | — | 1 | 5.87 |
| CHEMBL224252 | — | — | 1 | 5.71 |
| CHEMBL123 | ELLIPTECINE | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL224767 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL375931 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL224724 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL11269 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL224181 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL224647 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL223961 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL224254 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL223818 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL224794 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL387701 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL224682 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL11645 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL224252 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL123 | ELLIPTECINE | IC50 | = | 5970.0 | nM | 5.22 |