Assay Detail
ADMET
CHEMBL917816
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Cytotoxicity against human HT1080 cells after 3 days by SRB assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of 6-chloroisoquinoline-5,8-diones and pyrido[3,4-b]phenazine-5,12-diones and evaluation of their cytotoxicity and DNA topoisomerase II inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.62 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL224647 | — | — | 1 | 6.30 |
| CHEMBL224767 | — | — | 1 | 6.26 |
| CHEMBL223961 | — | — | 1 | 6.09 |
| CHEMBL223818 | — | — | 1 | 6.09 |
| CHEMBL11269 | — | — | 1 | 5.96 |
| CHEMBL375931 | — | — | 1 | 5.94 |
| CHEMBL11645 | — | — | 1 | 5.81 |
| CHEMBL224254 | — | — | 1 | 5.36 |
| CHEMBL123 | ELLIPTECINE | — | 1 | 5.30 |
| CHEMBL224724 | — | — | 1 | 5.15 |
| CHEMBL387701 | — | — | 1 | 5.02 |
| CHEMBL224252 | — | — | 1 | 4.98 |
| CHEMBL224682 | — | — | 1 | 4.83 |
| CHEMBL224181 | — | — | 1 | - |
| CHEMBL224794 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL224647 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL224767 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL223961 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL223818 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL11269 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL375931 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL11645 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL224254 | — | IC50 | = | 4360.0 | nM | 5.36 |
| CHEMBL123 | ELLIPTECINE | IC50 | = | 5010.0 | nM | 5.30 |
| CHEMBL224724 | — | IC50 | = | 7010.0 | nM | 5.15 |
| CHEMBL387701 | — | IC50 | = | 9540.0 | nM | 5.02 |
| CHEMBL224252 | — | IC50 | = | 10380.0 | nM | 4.98 |
| CHEMBL224682 | — | IC50 | = | 14890.0 | nM | 4.83 |
| CHEMBL224181 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL224794 | — | IC50 | > | 20000.0 | nM | - |