Assay Detail
ADMET
CHEMBL917817
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Cytotoxicity against human HL60 cells after 3 days by SRB assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of 6-chloroisoquinoline-5,8-diones and pyrido[3,4-b]phenazine-5,12-diones and evaluation of their cytotoxicity and DNA topoisomerase II inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.03 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11269 | — | — | 1 | 6.82 |
| CHEMBL224767 | — | — | 1 | 6.43 |
| CHEMBL224647 | — | — | 1 | 6.40 |
| CHEMBL387701 | — | — | 1 | 6.29 |
| CHEMBL224254 | — | — | 1 | 6.28 |
| CHEMBL223818 | — | — | 1 | 6.12 |
| CHEMBL11645 | — | — | 1 | 6.11 |
| CHEMBL224724 | — | — | 1 | 6.08 |
| CHEMBL375931 | — | — | 1 | 5.94 |
| CHEMBL224181 | — | — | 1 | 5.94 |
| CHEMBL224682 | — | — | 1 | 5.68 |
| CHEMBL123 | ELLIPTECINE | — | 1 | 5.58 |
| CHEMBL224252 | — | — | 1 | 5.58 |
| CHEMBL224794 | — | — | 1 | 5.21 |
| CHEMBL223961 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11269 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL224767 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL224647 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL387701 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL224254 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL223818 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL11645 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL224724 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL375931 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL224181 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL224682 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL123 | ELLIPTECINE | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL224252 | — | IC50 | = | 2640.0 | nM | 5.58 |
| CHEMBL224794 | — | IC50 | = | 6220.0 | nM | 5.21 |
| CHEMBL223961 | — | IC50 | > | 20000.0 | nM | - |