Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL917988

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]NECA from human recombinant adenosine A3 receptor expressed in CHO cells
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Expert

Target

Adenosine receptor A3 (CHEMBL256)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor.
Volpini R, Dal Ben D, Lambertucci C, Taffi S, Vittori S, Klotz KN, Cristalli G.
J Med Chem (2007) 50 : 1222 -1230
PubMed 17309246 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 36 8.28 8.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL223514 1 8.96
CHEMBL374462 1 8.80
CHEMBL385771 1 8.77
CHEMBL223326 1 8.77
CHEMBL221206 1 8.72
CHEMBL427077 1 8.72
CHEMBL223327 1 8.64
CHEMBL223625 1 8.60
CHEMBL375301 1 8.55
CHEMBL220889 1 8.55
CHEMBL385770 1 8.52
CHEMBL220386 1 8.49
CHEMBL223456 1 8.48
CHEMBL374242 1 8.46
CHEMBL220335 1 8.43
CHEMBL441707 1 8.42
CHEMBL223786 1 8.40
CHEMBL375619 1 8.39
CHEMBL220158 1 8.37
CHEMBL223739 1 8.36
CHEMBL223740 1 8.28
CHEMBL219888 1 8.27
CHEMBL426537 1 8.23
CHEMBL220899 1 8.22
CHEMBL223270 1 8.21
CHEMBL374792 1 8.17
CHEMBL1162942 1 8.14
CHEMBL223472 1 8.13
CHEMBL223328 1 8.10
CHEMBL267421 1 7.89

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL223514 Ki = 1.1 nM 8.96
CHEMBL374462 Ki = 1.6 nM 8.80
CHEMBL223326 Ki = 1.7 nM 8.77
CHEMBL385771 Ki = 1.7 nM 8.77
CHEMBL221206 Ki = 1.9 nM 8.72
CHEMBL427077 Ki = 1.9 nM 8.72
CHEMBL223327 Ki = 2.3 nM 8.64
CHEMBL223625 Ki = 2.5 nM 8.60
CHEMBL375301 Ki = 2.8 nM 8.55
CHEMBL220889 Ki = 2.8 nM 8.55
CHEMBL385770 Ki = 3.0 nM 8.52
CHEMBL220386 Ki = 3.2 nM 8.49
CHEMBL223456 Ki = 3.3 nM 8.48
CHEMBL374242 Ki = 3.5 nM 8.46
CHEMBL220335 Ki = 3.7 nM 8.43
CHEMBL441707 Ki = 3.8 nM 8.42
CHEMBL223786 Ki = 4.0 nM 8.40
CHEMBL375619 Ki = 4.1 nM 8.39
CHEMBL220158 Ki = 4.3 nM 8.37
CHEMBL223739 Ki = 4.4 nM 8.36
CHEMBL223740 Ki = 5.2 nM 8.28
CHEMBL219888 Ki = 5.4 nM 8.27
CHEMBL426537 Ki = 5.9 nM 8.23
CHEMBL220899 Ki = 6.0 nM 8.22
CHEMBL223270 Ki = 6.2 nM 8.21
CHEMBL374792 Ki = 6.8 nM 8.17
CHEMBL1162942 Ki = 7.3 nM 8.14
CHEMBL223472 Ki = 7.4 nM 8.13
CHEMBL223328 Ki = 7.9 nM 8.10
CHEMBL267421 Ki = 13.0 nM 7.89
CHEMBL375190 Ki = 16.0 nM 7.80
CHEMBL373578 Ki = 23.0 nM 7.64
CHEMBL374019 Ki = 23.0 nM 7.64
CHEMBL374320 Ki = 39.0 nM 7.41
CHEMBL220334 Ki = 55.0 nM 7.26
CHEMBL374336 Ki = 68.0 nM 7.17