Compound Detail
CHEMBL220158
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CONc1nc(C#Cc2ccc(OC)cc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Basic Information
| ChEMBL ID | CHEMBL220158 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MZYNTNQYNANXII-AEVYOOLXSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
427.4
MW (Da)
-0.18
ALogP
11
HBA
4
HBD
144.0
PSA (Ų)
0.32
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 8.37
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Adenosine receptor A3 CHEMBL256 | Ki | 8.37 | 8.37 | 4.3 | 1 |
| Adenosine receptor A2a CHEMBL251 | Ki | 5.75 | 5.75 | 1780.0 | 1 |
| Adenosine receptor A1 CHEMBL226 | Ki | 5.73 | 5.73 | 1870.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Adenosine receptor A3 | Ki | = | 4.3 | nM | 8.37 | Displacement of [3H]NECA from human recombinant adenosine A3 receptor expressed ... | 17309246 |
| Adenosine receptor A2a | Ki | = | 1780.0 | nM | 5.75 | Displacement of [3H]NECA from human recombinant adenosine A2A receptor expressed... | 17309246 |
| Adenosine receptor A1 | Ki | = | 1870.0 | nM | 5.73 | Displacement of [3H]CCPA from human recombinant adenosine A1 receptor expressed ... | 17309246 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17309246 | 10.1021/jm060963u | Adenosine receptor A1 | 1 |
| 17309246 | 10.1021/jm060963u | Adenosine receptor A2a | 1 |
| 17309246 | 10.1021/jm060963u | Adenosine receptor A3 | 1 |
| 17309246 | 10.1021/jm060963u | Adenosine receptors; A1 & A3 | 1 |
| 17309246 | 10.1021/jm060963u | Adenosine receptors; A2a & A3 | 1 |
Data from ChEMBL 36 via Core Engine