Assay Detail
Binding
CHEMBL917987
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Displacement of [3H]NECA from human recombinant adenosine A2A receptor expressed in CHO cells
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 36 | 5.35 | 7.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223326 | — | — | 1 | 7.04 |
| CHEMBL220889 | — | — | 1 | 6.57 |
| CHEMBL375190 | — | — | 1 | 6.44 |
| CHEMBL223270 | — | — | 1 | 6.21 |
| CHEMBL219888 | — | — | 1 | 6.12 |
| CHEMBL220158 | — | — | 1 | 5.75 |
| CHEMBL1162942 | — | — | 1 | 5.75 |
| CHEMBL375619 | — | — | 1 | 5.74 |
| CHEMBL385770 | — | — | 1 | 5.57 |
| CHEMBL223327 | — | — | 1 | 5.53 |
| CHEMBL220335 | — | — | 1 | 5.51 |
| CHEMBL223740 | — | — | 1 | 5.50 |
| CHEMBL374019 | — | — | 1 | 5.50 |
| CHEMBL223739 | — | — | 1 | 5.40 |
| CHEMBL223786 | — | — | 1 | 5.38 |
| CHEMBL441707 | — | — | 1 | 5.37 |
| CHEMBL374792 | — | — | 1 | 5.34 |
| CHEMBL375301 | — | — | 1 | 5.28 |
| CHEMBL267421 | — | — | 1 | 5.24 |
| CHEMBL220386 | — | — | 1 | 5.20 |
| CHEMBL220899 | — | — | 1 | 5.20 |
| CHEMBL374462 | — | — | 1 | 5.19 |
| CHEMBL374320 | — | — | 1 | 5.19 |
| CHEMBL374242 | — | — | 1 | 5.18 |
| CHEMBL373578 | — | — | 1 | 5.08 |
| CHEMBL223625 | — | — | 1 | 4.98 |
| CHEMBL385771 | — | — | 1 | 4.92 |
| CHEMBL223472 | — | — | 1 | 4.91 |
| CHEMBL223328 | — | — | 1 | 4.90 |
| CHEMBL223456 | — | — | 1 | 4.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223326 | — | Ki | = | 91.0 | nM | 7.04 |
| CHEMBL220889 | — | Ki | = | 267.0 | nM | 6.57 |
| CHEMBL375190 | — | Ki | = | 363.0 | nM | 6.44 |
| CHEMBL223270 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL219888 | — | Ki | = | 758.0 | nM | 6.12 |
| CHEMBL220158 | — | Ki | = | 1780.0 | nM | 5.75 |
| CHEMBL1162942 | — | Ki | = | 1760.0 | nM | 5.75 |
| CHEMBL375619 | — | Ki | = | 1820.0 | nM | 5.74 |
| CHEMBL385770 | — | Ki | = | 2680.0 | nM | 5.57 |
| CHEMBL223327 | — | Ki | = | 2960.0 | nM | 5.53 |
| CHEMBL220335 | — | Ki | = | 3080.0 | nM | 5.51 |
| CHEMBL223740 | — | Ki | = | 3130.0 | nM | 5.50 |
| CHEMBL374019 | — | Ki | = | 3140.0 | nM | 5.50 |
| CHEMBL223739 | — | Ki | = | 3960.0 | nM | 5.40 |
| CHEMBL223786 | — | Ki | = | 4210.0 | nM | 5.38 |
| CHEMBL441707 | — | Ki | = | 4290.0 | nM | 5.37 |
| CHEMBL374792 | — | Ki | = | 4600.0 | nM | 5.34 |
| CHEMBL375301 | — | Ki | = | 5290.0 | nM | 5.28 |
| CHEMBL267421 | — | Ki | = | 5740.0 | nM | 5.24 |
| CHEMBL220899 | — | Ki | = | 6310.0 | nM | 5.20 |
| CHEMBL220386 | — | Ki | = | 6290.0 | nM | 5.20 |
| CHEMBL374462 | — | Ki | = | 6460.0 | nM | 5.19 |
| CHEMBL374320 | — | Ki | = | 6520.0 | nM | 5.19 |
| CHEMBL374242 | — | Ki | = | 6660.0 | nM | 5.18 |
| CHEMBL373578 | — | Ki | = | 8270.0 | nM | 5.08 |
| CHEMBL223625 | — | Ki | = | 10400.0 | nM | 4.98 |
| CHEMBL385771 | — | Ki | = | 12100.0 | nM | 4.92 |
| CHEMBL223472 | — | Ki | = | 12400.0 | nM | 4.91 |
| CHEMBL223328 | — | Ki | = | 12500.0 | nM | 4.90 |
| CHEMBL223456 | — | Ki | = | 14700.0 | nM | 4.83 |
| CHEMBL221206 | — | Ki | = | 16300.0 | nM | 4.79 |
| CHEMBL223514 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL427077 | — | Ki | = | 18700.0 | nM | 4.73 |
| CHEMBL374336 | — | Ki | = | 27100.0 | nM | 4.57 |
| CHEMBL220334 | — | Ki | = | 31700.0 | nM | 4.50 |
| CHEMBL426537 | — | Ki | = | 35100.0 | nM | 4.46 |