Assay Detail
Binding
CHEMBL918070
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Inhibition of tubulin polymerization
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Arylthioindoles, potent inhibitors of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.42 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL89341 | — | — | 1 | 5.80 |
| CHEMBL221765 | — | — | 1 | 5.70 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.66 |
| CHEMBL381933 | — | — | 1 | 5.60 |
| CHEMBL389169 | — | — | 1 | 5.54 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.50 |
| CHEMBL327414 | — | — | 1 | 5.39 |
| CHEMBL313011 | — | — | 1 | 5.36 |
| CHEMBL313989 | — | — | 1 | 5.36 |
| CHEMBL223922 | — | — | 1 | 5.21 |
| CHEMBL286404 | — | — | 1 | 5.08 |
| CHEMBL222228 | — | — | 1 | 4.82 |
| CHEMBL145872 | — | — | 1 | - |
| CHEMBL390534 | — | — | 1 | - |
| CHEMBL376312 | — | — | 1 | - |
| CHEMBL373536 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL89341 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL221765 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL381933 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL389169 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL107 | COLCHICINE | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL327414 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL313011 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL313989 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL223922 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL286404 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL222228 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL145872 | — | IC50 | - | — | - | |
| CHEMBL390534 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL376312 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL373536 | — | IC50 | > | 40000.0 | nM | - |