Assay Detail
Functional
CHEMBL918090
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
25
Total Activities
25
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
alpha 2-adrenoreceptors profile modulation. 2. Biphenyline analogues as tools for selective activation of the alpha 2C-subtype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 16 | - | - |
| EC50 | 9 | 6.65 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223829 | — | — | 1 | 7.38 |
| CHEMBL385310 | — | — | 1 | 7.12 |
| CHEMBL223836 | — | — | 1 | 6.98 |
| CHEMBL128168 | BIPHENYLINE | — | 1 | 6.94 |
| CHEMBL222371 | — | — | 1 | 6.59 |
| CHEMBL373535 | — | — | 1 | 6.50 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 6.43 |
| CHEMBL130884 | — | — | 1 | 6.41 |
| CHEMBL222933 | — | — | 1 | 5.46 |
| CHEMBL221989 | — | — | 1 | - |
| CHEMBL222593 | — | — | 1 | - |
| CHEMBL222592 | — | — | 1 | - |
| CHEMBL222591 | — | — | 1 | - |
| CHEMBL1204386 | — | — | 1 | - |
| CHEMBL374954 | — | — | 1 | - |
| CHEMBL221523 | — | — | 1 | - |
| CHEMBL222928 | — | — | 1 | - |
| CHEMBL222138 | — | — | 1 | - |
| CHEMBL222798 | — | — | 1 | - |
| CHEMBL374584 | — | — | 1 | - |
| CHEMBL426900 | — | — | 1 | - |
| CHEMBL222973 | — | — | 1 | - |
| CHEMBL223830 | — | — | 1 | - |
| CHEMBL442045 | — | — | 1 | - |
| CHEMBL373830 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223829 | — | EC50 | = | 41.69 | nM | 7.38 |
| CHEMBL385310 | — | EC50 | = | 75.86 | nM | 7.12 |
| CHEMBL223836 | — | EC50 | = | 104.71 | nM | 6.98 |
| CHEMBL128168 | BIPHENYLINE | EC50 | = | 114.82 | nM | 6.94 |
| CHEMBL222371 | — | EC50 | = | 257.04 | nM | 6.59 |
| CHEMBL373535 | — | EC50 | = | 316.23 | nM | 6.50 |
| CHEMBL1437 | NOREPINEPHRINE | EC50 | = | 371.54 | nM | 6.43 |
| CHEMBL130884 | — | EC50 | = | 389.05 | nM | 6.41 |
| CHEMBL222933 | — | EC50 | = | 3467.37 | nM | 5.46 |
| CHEMBL221989 | — | Activity | - | — | - | |
| CHEMBL222593 | — | Activity | - | — | - | |
| CHEMBL222592 | — | Activity | - | — | - | |
| CHEMBL222591 | — | Activity | - | — | - | |
| CHEMBL1204386 | — | Activity | - | — | - | |
| CHEMBL374954 | — | Activity | - | — | - | |
| CHEMBL221523 | — | Activity | - | — | - | |
| CHEMBL222928 | — | Activity | - | — | - | |
| CHEMBL222138 | — | Activity | - | — | - | |
| CHEMBL222798 | — | Activity | - | — | - | |
| CHEMBL374584 | — | Activity | - | — | - | |
| CHEMBL426900 | — | Activity | - | — | - | |
| CHEMBL222973 | — | Activity | - | — | - | |
| CHEMBL223830 | — | Activity | - | — | - | |
| CHEMBL442045 | — | Activity | - | — | - | |
| CHEMBL373830 | — | Activity | - | — | - |