Assay Detail
Binding
CHEMBL918106
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Inhibition of Escherichia coli TEM1
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.08 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122450 | — | — | 1 | 9.00 |
| CHEMBL222375 | — | — | 1 | 8.52 |
| CHEMBL388778 | — | — | 1 | 8.22 |
| CHEMBL222922 | — | — | 1 | 8.10 |
| CHEMBL222866 | — | — | 1 | 8.05 |
| CHEMBL222758 | — | — | 1 | 8.00 |
| CHEMBL375172 | — | — | 1 | 7.75 |
| CHEMBL1439 | TAZOBACTAM SODIUM | 4.0 | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122450 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL222375 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL388778 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL222922 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL222866 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL222758 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL375172 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1439 | TAZOBACTAM SODIUM | IC50 | = | 100.0 | nM | 7.00 |