Assay Detail
Binding
CHEMBL918145
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Inhibition of HIV1 reverse transcriptase
15
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis of AZT 5'-triphosphate mimics and their inhibitory effects on HIV-1 reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.93 | 8.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | -1.0 | 1 | 8.08 |
| CHEMBL388190 | — | — | 2 | 8.02 |
| CHEMBL224851 | — | — | 1 | 8.02 |
| CHEMBL223954 | — | — | 1 | 7.57 |
| CHEMBL225237 | — | — | 1 | 7.39 |
| CHEMBL223397 | — | — | 2 | 7.13 |
| CHEMBL224591 | — | — | 1 | 6.91 |
| CHEMBL390131 | — | — | 1 | 6.63 |
| CHEMBL224698 | — | — | 1 | 6.59 |
| CHEMBL390120 | — | — | 1 | 6.52 |
| CHEMBL389694 | — | — | 1 | 6.38 |
| CHEMBL388851 | — | — | 1 | 6.22 |
| CHEMBL224567 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL388190 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL224851 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL223954 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL225237 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL223397 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL223397 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL224591 | — | Ki | = | 124.0 | nM | 6.91 |
| CHEMBL390131 | — | Ki | = | 234.0 | nM | 6.63 |
| CHEMBL224698 | — | Ki | = | 254.0 | nM | 6.59 |
| CHEMBL390120 | — | Ki | = | 303.0 | nM | 6.52 |
| CHEMBL389694 | — | Ki | = | 415.0 | nM | 6.38 |
| CHEMBL388851 | — | Ki | = | 597.0 | nM | 6.22 |
| CHEMBL224567 | — | Ki | = | 852.0 | nM | 6.07 |
| CHEMBL388190 | — | Ki | = | 4560.0 | nM | 5.34 |