Compound Detail
CHEMBL224851
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BP(=O)(OC[C@@H]1O[C@H](n2cc(C)c(=O)[nH]c2=O)C[C@H]1N=[N+]=[N-])OP(=O)(O)OP(=O)(O)O
Basic Information
| ChEMBL ID | CHEMBL224851 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JKCDENMGDSYJEP-YMWPKTBISA-N |
1
Targets
1
Activities
1
Assay Types
4
PK Parameters
3
Publications
0
Known Names
Molecular Properties
503.0
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 8.02
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | Ki | 8.02 | 8.02 | 9.6 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 6.0 | hr | Bos taurus |
| T1/2 | 6.0 | hr | Bos taurus |
| t1/2 | - | - | Homo sapiens |
| t1/2 | - | - | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | Ki | = | 9.6 | nM | 8.02 | Inhibition of HIV1 reverse transcriptase | 15615539 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15615539 | 10.1021/jm040116w | Unchecked | 2 |
| 15615539 | 10.1021/jm040116w | Serum | 2 |
| 15615539 | 10.1021/jm040116w | CCRF-CEM | 2 |
Data from ChEMBL 36 via Core Engine