Assay Detail
Binding
CHEMBL918457
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Inhibition of HCV 1b BK NS5B delta21 RNA polymerase expressed in Escherichia coli
45
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1b |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of anthranilic acid derivatives as a novel class of allosteric inhibitors of hepatitis C NS5B polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 6.32 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL228024 | — | — | 1 | 8.00 |
| CHEMBL227745 | — | — | 1 | 7.77 |
| CHEMBL227776 | — | — | 1 | 7.66 |
| CHEMBL228157 | — | — | 1 | 7.52 |
| CHEMBL228074 | — | — | 1 | 7.52 |
| CHEMBL227886 | — | — | 1 | 7.50 |
| CHEMBL387910 | — | — | 1 | 7.10 |
| CHEMBL427454 | — | — | 1 | 6.96 |
| CHEMBL227691 | — | — | 1 | 6.96 |
| CHEMBL388841 | — | — | 1 | 6.96 |
| CHEMBL228088 | — | — | 1 | 6.85 |
| CHEMBL228233 | — | — | 1 | 6.77 |
| CHEMBL376104 | — | — | 1 | 6.75 |
| CHEMBL227710 | — | — | 1 | 6.70 |
| CHEMBL228234 | — | — | 1 | 6.68 |
| CHEMBL227885 | — | — | 1 | 6.68 |
| CHEMBL228087 | — | — | 1 | 6.64 |
| CHEMBL427451 | — | — | 1 | 6.64 |
| CHEMBL227715 | — | — | 1 | 6.35 |
| CHEMBL390765 | — | — | 1 | 6.28 |
| CHEMBL389247 | — | — | 1 | 6.24 |
| CHEMBL388519 | — | — | 1 | 6.24 |
| CHEMBL227810 | — | — | 1 | 6.12 |
| CHEMBL228019 | — | — | 1 | 6.07 |
| CHEMBL228151 | — | — | 2 | 6.06 |
| CHEMBL228015 | — | — | 1 | 5.98 |
| CHEMBL375909 | — | — | 1 | 5.94 |
| CHEMBL227635 | — | — | 1 | 5.90 |
| CHEMBL388952 | — | — | 1 | 5.82 |
| CHEMBL227439 | — | — | 1 | 5.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL228024 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL227745 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL227776 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL228157 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL228074 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL227886 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL387910 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL427454 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL227691 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL388841 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL228088 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL228233 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL376104 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL227710 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL227885 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL228234 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL228087 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL427451 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL227715 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL390765 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL388519 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL389247 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL227810 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL228019 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL228151 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL228151 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL228015 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL375909 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL227635 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL388952 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL227439 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL228246 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL227826 | — | IC50 | = | 3230.0 | nM | 5.49 |
| CHEMBL227831 | — | IC50 | = | 3360.0 | nM | 5.47 |
| CHEMBL389673 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL226665 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL388635 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL224126 | — | IC50 | = | 7470.0 | nM | 5.13 |
| CHEMBL228244 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL425495 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL227659 | — | IC50 | > | 31000.0 | nM | - |
| CHEMBL427450 | — | IC50 | > | 28000.0 | nM | - |
| CHEMBL383582 | — | IC50 | > | 37000.0 | nM | - |
| CHEMBL222582 | — | IC50 | > | 33000.0 | nM | - |
| CHEMBL228029 | — | IC50 | > | 30000.0 | nM | - |