Assay Detail

CHEMBL918543

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Functional

Inhibition of A-23187-stimulated 15-HETE production in human whole blood

ChEMBL ↗

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Target

Blood (CHEMBL613416) ↗

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Primary target Blood

CHEMBL613416

Anchored from Assay target.

Protein identity Blood

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Tissue	Blood
Confidence	1 — Organism
Curated By	Autocuration

Target

Blood (CHEMBL613416) ↗

Type	TISSUE
Organism	Homo sapiens

Publication

Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha.

Lee KL, Foley MA, Chen L, Behnke ML, Lovering FE, Kirincich SJ, Wang W, Shim J, Tam S, Shen MW, Khor S, Xu X, Goodwin DG, Ramarao MK, Nickerson-Nutter C, Donahue F, Ku MS, Clark JD, McKew JC.
J Med Chem (2007) 50 : 1380 -1400
PubMed 17305324 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.52	6.52

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL269787	ECOPLADIB	2.0	1	6.52

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL269787	ECOPLADIB	IC50	=	300.0	nM	6.52