Assay Detail
Binding
CHEMBL918630
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Inhibition of human BChE
65
Total Activities
65
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 65 | 4.71 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL374331 | — | — | 1 | 5.62 |
| CHEMBL373781 | — | — | 1 | 5.17 |
| CHEMBL374758 | — | — | 1 | 5.13 |
| CHEMBL426562 | — | — | 1 | 4.91 |
| CHEMBL375126 | — | — | 1 | 4.90 |
| CHEMBL222851 | — | — | 1 | 4.74 |
| CHEMBL222149 | — | — | 1 | 4.72 |
| CHEMBL375304 | — | — | 1 | 4.68 |
| CHEMBL376291 | — | — | 1 | 4.66 |
| CHEMBL223000 | — | — | 1 | 4.55 |
| CHEMBL222190 | — | — | 1 | 4.51 |
| CHEMBL221830 | — | — | 1 | 4.25 |
| CHEMBL117447 | PHENYL ISATIN | — | 1 | 4.16 |
| CHEMBL222795 | — | — | 1 | 4.00 |
| CHEMBL376518 | — | — | 1 | - |
| CHEMBL223001 | — | — | 1 | - |
| CHEMBL222891 | — | — | 1 | - |
| CHEMBL386000 | — | — | 1 | - |
| CHEMBL374970 | — | — | 1 | - |
| CHEMBL222989 | — | — | 1 | - |
| CHEMBL79466 | — | — | 1 | - |
| CHEMBL115581 | — | — | 1 | - |
| CHEMBL221362 | — | — | 1 | - |
| CHEMBL222711 | — | — | 1 | - |
| CHEMBL222712 | — | — | 1 | - |
| CHEMBL385132 | — | — | 1 | - |
| CHEMBL221873 | — | — | 1 | - |
| CHEMBL442046 | — | — | 1 | - |
| CHEMBL118883 | — | — | 1 | - |
| CHEMBL376228 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL374331 | — | Ki | = | 2390.0 | nM | 5.62 |
| CHEMBL373781 | — | Ki | = | 6710.0 | nM | 5.17 |
| CHEMBL374758 | — | Ki | = | 7400.0 | nM | 5.13 |
| CHEMBL426562 | — | Ki | = | 12300.0 | nM | 4.91 |
| CHEMBL375126 | — | Ki | = | 12600.0 | nM | 4.90 |
| CHEMBL222851 | — | Ki | = | 18100.0 | nM | 4.74 |
| CHEMBL222149 | — | Ki | = | 18900.0 | nM | 4.72 |
| CHEMBL375304 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL376291 | — | Ki | = | 21900.0 | nM | 4.66 |
| CHEMBL223000 | — | Ki | = | 28100.0 | nM | 4.55 |
| CHEMBL222190 | — | Ki | = | 30600.0 | nM | 4.51 |
| CHEMBL221830 | — | Ki | = | 56500.0 | nM | 4.25 |
| CHEMBL117447 | PHENYL ISATIN | Ki | = | 68800.0 | nM | 4.16 |
| CHEMBL222795 | — | Ki | = | 98900.0 | nM | 4.00 |
| CHEMBL60569 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL326294 | ISATIN | Ki | > | 100000.0 | nM | - |
| CHEMBL223254 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL222752 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL221512 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL222644 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL222849 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL374905 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL221669 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL376290 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL373715 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL222292 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL374740 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL222988 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL223039 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL385800 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL385799 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL333636 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL115581 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL376228 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL118883 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL442046 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL221873 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL385132 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL222712 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL222711 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL221362 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL225175 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL79466 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL222989 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL374970 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL386000 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL222891 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL223001 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL376518 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL222999 | — | Ki | > | 100000.0 | nM | - |