Assay Detail
Functional
CHEMBL918634
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against wild type HIV1 3B in MT4 cells after 4 days by MTT method
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and anti-HIV-1 activity evaluation of 5-alkyl-2-alkylthio-6-(arylcarbonyl or alpha-cyanoarylmethyl)-3,4-dihydropyrimidin-4(3H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.78 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL374286 | — | — | 1 | 8.70 |
| CHEMBL388744 | — | — | 1 | 7.05 |
| CHEMBL223364 | — | — | 1 | 6.75 |
| CHEMBL376073 | — | — | 1 | 6.62 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.60 |
| CHEMBL375081 | — | — | 1 | 6.24 |
| CHEMBL375822 | — | — | 1 | 6.19 |
| CHEMBL222411 | — | — | 1 | 6.18 |
| CHEMBL221874 | — | — | 1 | 6.10 |
| CHEMBL222148 | — | — | 1 | 5.93 |
| CHEMBL269554 | — | — | 1 | 5.90 |
| CHEMBL222245 | — | — | 1 | 5.88 |
| CHEMBL222749 | — | — | 1 | 5.87 |
| CHEMBL375856 | — | — | 1 | 5.69 |
| CHEMBL222246 | — | — | 1 | 5.65 |
| CHEMBL375305 | — | — | 1 | 5.57 |
| CHEMBL225195 | — | — | 1 | 5.45 |
| CHEMBL223728 | — | — | 1 | 5.33 |
| CHEMBL222991 | — | — | 1 | 5.33 |
| CHEMBL225268 | — | — | 1 | 5.31 |
| CHEMBL31871 | HEPT | — | 1 | 5.30 |
| CHEMBL426720 | — | — | 1 | 5.20 |
| CHEMBL222609 | — | — | 1 | 5.17 |
| CHEMBL221876 | — | — | 1 | 5.14 |
| CHEMBL222663 | — | — | 1 | 4.96 |
| CHEMBL222441 | — | — | 1 | 4.77 |
| CHEMBL374115 | — | — | 1 | 4.55 |
| CHEMBL222193 | — | — | 1 | 4.42 |
| CHEMBL221878 | — | — | 1 | - |
| CHEMBL386001 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL374286 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL388744 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL223364 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL376073 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL375081 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL375822 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL222411 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL221874 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL222148 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL269554 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL222245 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL222749 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL375856 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL222246 | — | IC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL375305 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL225195 | — | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL223728 | — | IC50 | = | 4710.0 | nM | 5.33 |
| CHEMBL222991 | — | IC50 | = | 4690.0 | nM | 5.33 |
| CHEMBL225268 | — | IC50 | = | 4850.0 | nM | 5.31 |
| CHEMBL31871 | HEPT | IC50 | = | 5060.0 | nM | 5.30 |
| CHEMBL426720 | — | IC50 | = | 6340.0 | nM | 5.20 |
| CHEMBL222609 | — | IC50 | = | 6790.0 | nM | 5.17 |
| CHEMBL221876 | — | IC50 | = | 7280.0 | nM | 5.14 |
| CHEMBL222663 | — | IC50 | = | 10870.0 | nM | 4.96 |
| CHEMBL222441 | — | IC50 | = | 16940.0 | nM | 4.77 |
| CHEMBL374115 | — | IC50 | = | 27840.0 | nM | 4.55 |
| CHEMBL222193 | — | IC50 | = | 37580.0 | nM | 4.42 |
| CHEMBL223365 | — | IC50 | > | 21030.0 | nM | - |
| CHEMBL388776 | — | IC50 | > | 23530.0 | nM | - |
| CHEMBL373608 | — | IC50 | > | 2090.0 | nM | - |
| CHEMBL221661 | — | IC50 | > | 246650.0 | nM | - |
| CHEMBL221354 | — | IC50 | > | 123560.0 | nM | - |
| CHEMBL222488 | — | IC50 | >= | 35730.0 | nM | - |
| CHEMBL223777 | — | IC50 | > | 312500.0 | nM | - |
| CHEMBL374299 | — | IC50 | >= | 60750.0 | nM | - |
| CHEMBL386001 | — | IC50 | > | 22800.0 | nM | - |
| CHEMBL221878 | — | IC50 | > | 304410.0 | nM | - |