Assay Detail
Functional
CHEMBL918647
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of MCF7 cells expressing ER and antiestrogen binding sites
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Anti-estrogen binding site (AEBS) (CHEMBL612409) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Antiestrogen binding site and estrogen receptor mediate uptake and distribution of 4-hydroxytamoxifen-targeted doxorubicin-formaldehyde conjugate in breast cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.13 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222694 | — | — | 1 | 7.52 |
| CHEMBL266892 | — | — | 1 | 7.16 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222694 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL266892 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 200.0 | nM | 6.70 |