Assay Detail
Functional
CHEMBL918649
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Growth inhibition of ER expressing Rtx6 cells after 4 hrs
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiestrogen binding site and estrogen receptor mediate uptake and distribution of 4-hydroxytamoxifen-targeted doxorubicin-formaldehyde conjugate in breast cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.03 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL266892 | — | — | 1 | 7.21 |
| CHEMBL222694 | — | — | 1 | 7.17 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL266892 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL222694 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 200.0 | nM | 6.70 |