Assay Detail
Functional
CHEMBL918682
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitumor activity against human NCI CNS cancer cell line panel
6
Total Activities
3
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antitumor activity of methyltriazene prodrugs simultaneously releasing DNA-methylating agents and the antiresistance drug O(6)-benzylguanine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.45 | 5.05 |
| TGI | 2 | - | - |
| LC50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL387940 | — | — | 3 | 5.05 |
| CHEMBL223089 | — | — | 2 | 4.26 |
| CHEMBL810 | TEMOZOLOMIDE | 4.0 | 1 | 4.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL387940 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL223089 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL810 | TEMOZOLOMIDE | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL387940 | — | TGI | = | 30000.0 | nM | - |
| CHEMBL387940 | — | LC50 | = | 47000.0 | nM | - |
| CHEMBL223089 | — | TGI | > | 100000.0 | nM | - |