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Assay Detail

CHEMBL918796

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Binding
Inhibition of MMP1
13
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Interstitial collagenase (CHEMBL332)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

alpha-Biphenylsulfonylamino 2-methylpropyl phosphonates: enantioselective synthesis and selective inhibition of MMPs.
Biasone A, Tortorella P, Campestre C, Agamennone M, Preziuso S, Chiappini M, Nuti E, Carelli P, Rossello A, Mazza F, Gallina C.
Bioorg Med Chem (2007) 15 : 791 -799
PubMed 17088065 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 6.43 7.11

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL376557 1 7.11
CHEMBL227484 2 7.01
CHEMBL202932 1 6.82
CHEMBL374377 1 6.80
CHEMBL227501 1 6.50
CHEMBL228188 1 6.50
CHEMBL227824 1 6.35
CHEMBL228187 1 6.23
CHEMBL227598 1 6.22
CHEMBL418442 1 5.38
CHEMBL296196 1 5.19
CHEMBL389898 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL376557 IC50 = 77.0 nM 7.11
CHEMBL227484 IC50 = 98.0 nM 7.01
CHEMBL227484 IC50 = 98.0 nM 7.01
CHEMBL202932 IC50 = 150.0 nM 6.82
CHEMBL374377 IC50 = 160.0 nM 6.80
CHEMBL227501 IC50 = 320.0 nM 6.50
CHEMBL228188 IC50 = 320.0 nM 6.50
CHEMBL227824 IC50 = 450.0 nM 6.35
CHEMBL228187 IC50 = 590.0 nM 6.23
CHEMBL227598 IC50 = 600.0 nM 6.22
CHEMBL418442 IC50 = 4200.0 nM 5.38
CHEMBL296196 IC50 = 6500.0 nM 5.19
CHEMBL389898 IC50 - -