Assay Detail
Functional
CHEMBL919536
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Effect on fatty acid oxidation in rat L6 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | L6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification and synthesis of a novel selective partial PPARdelta agonist with full efficacy on lipid metabolism in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.77 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL221399 | — | — | 1 | 8.52 |
| CHEMBL38943 | GW501516 | 2.0 | 1 | 8.22 |
| CHEMBL222880 | — | — | 1 | 7.52 |
| CHEMBL388540 | — | — | 1 | 6.69 |
| CHEMBL223080 | — | — | 1 | 6.67 |
| CHEMBL222560 | — | — | 1 | 6.65 |
| CHEMBL222561 | — | — | 1 | 6.42 |
| CHEMBL225017 | — | — | 1 | 6.21 |
| CHEMBL981 | FENOFIBRIC ACID | 4.0 | 1 | 5.52 |
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL221399 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL38943 | GW501516 | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL222880 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL388540 | — | EC50 | = | 204.0 | nM | 6.69 |
| CHEMBL223080 | — | EC50 | = | 212.0 | nM | 6.67 |
| CHEMBL222560 | — | EC50 | = | 224.0 | nM | 6.65 |
| CHEMBL222561 | — | EC50 | = | 379.0 | nM | 6.42 |
| CHEMBL225017 | — | EC50 | = | 615.0 | nM | 6.21 |
| CHEMBL981 | FENOFIBRIC ACID | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL121 | ROSIGLITAZONE | EC50 | = | 5000.0 | nM | 5.30 |