Assay Detail
Functional
CHEMBL919550
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Agonist activity at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
alpha 2-adrenoreceptors profile modulation. 2. Biphenyline analogues as tools for selective activation of the alpha 2C-subtype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.10 | 7.40 |
| Intrinsic activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL373535 | — | — | 2 | 7.40 |
| CHEMBL222928 | — | — | 2 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL373535 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL222928 | — | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL373535 | — | Intrinsic activity | = | 1.0 | — | - |
| CHEMBL222928 | — | Intrinsic activity | = | 0.6 | — | - |