Assay Detail
Binding
CHEMBL919554
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Inhibition of Mycobacterium tuberculosis TMPK by coupled spectrophotometric assay
14
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 4.57 | 5.46 |
| Km | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL375569 | — | — | 1 | 5.46 |
| CHEMBL222483 | — | — | 1 | 4.87 |
| CHEMBL1160604 | — | — | 1 | 4.72 |
| CHEMBL52609 | DOXRIBTIMINE | 2.0 | 1 | 4.57 |
| CHEMBL221894 | — | — | 1 | 4.54 |
| CHEMBL223779 | — | — | 1 | 4.43 |
| CHEMBL222185 | — | — | 1 | 4.40 |
| CHEMBL1160603 | — | — | 1 | 4.37 |
| CHEMBL341264 | — | — | 1 | 4.24 |
| CHEMBL222970 | — | — | 1 | 4.10 |
| CHEMBL394429 | THYMIDINE MONOPHOSPHATE | — | 1 | - |
| CHEMBL223811 | — | — | 1 | - |
| CHEMBL222242 | — | — | 1 | - |
| CHEMBL223135 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL375569 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL222483 | — | Ki | = | 13500.0 | nM | 4.87 |
| CHEMBL1160604 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL52609 | DOXRIBTIMINE | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL221894 | — | Ki | = | 29000.0 | nM | 4.54 |
| CHEMBL223779 | — | Ki | = | 37000.0 | nM | 4.43 |
| CHEMBL222185 | — | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL1160603 | — | Ki | = | 43000.0 | nM | 4.37 |
| CHEMBL341264 | — | Ki | = | 57000.0 | nM | 4.24 |
| CHEMBL222970 | — | Ki | = | 80000.0 | nM | 4.10 |
| CHEMBL394429 | THYMIDINE MONOPHOSPHATE | Km | = | 4500.0 | nM | - |
| CHEMBL223811 | — | Ki | = | 165000.0 | nM | - |
| CHEMBL222242 | — | Ki | = | 390000.0 | nM | - |
| CHEMBL223135 | — | Ki | = | 180000.0 | nM | - |