Assay Detail
Binding
CHEMBL919632
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Inhibition of RFC-mediated [3H]MTX influx into human CCRF-CEM cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and in vitro antifolate activity of rotationally restricted aminopterin and methotrexate analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.26 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL390990 | — | — | 1 | 6.55 |
| CHEMBL388501 | — | — | 1 | 6.28 |
| CHEMBL224946 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL390990 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL388501 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL224946 | — | Ki | = | 1100.0 | nM | 5.96 |