Assay Detail
Functional
CHEMBL919633
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Growth inhibition of human CCRF-CEM cells after 72 hrs
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and in vitro antifolate activity of rotationally restricted aminopterin and methotrexate analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.74 | 8.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL390990 | — | — | 1 | 8.29 |
| CHEMBL388501 | — | — | 1 | 8.08 |
| CHEMBL224946 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL390990 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL388501 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL224946 | — | IC50 | = | 140.0 | nM | 6.85 |